Stephen Harrison

  • Latest publications

    Bradley, T., Fera, D., Bhiman, J., Eslamizar, L., Lu, X., Anasti, K., Zhang, R., Sutherland, L.L., Scearce, R.M., Bowman, C.M., Stolarchuk, C., Lloyd, K.E., Parks, R., Eaton, A., Foulger, A., Nie, X., Karim, S.S.A., Barnett, S., Kelsoe, G., Kepler, T.B., Alam, S.M., Montefiori, D.C., Moody, M.A., Liao, H-X., Morris, L., Santra, S., Harrison,S.C. and Haynes, B.F. Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Reports 14: 43-54 (2016)

    Mahmutovic, S., Clark, L., Levis, S.C., Briggiler, A.M., Enria, D.A., Harrison, S.C., Abraham, J.A. Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses. Cell Host Microbe 18: 705-13 (2015).

    Ivanovic, T., Harrison, S.C. Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion. ELife, Nov. 27;4 eLife 2: e00333. eLife 2: 11009 (2015).

    Schmidt, A.G., Do, T.K., McCarthy, K.M., Kepler, T.B., Liao, H-X., Moody, M.A., Haynes, B.F., Harrison, S.C. Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site. Cell Reports 13: 2842-2850 (2015).

    Liang, B., Li, Z., Jenni, S., Rahmeh, A.A., Morin, B.M., Grant, T., Grigorieff, N., Harrison, S.C., Whelan, S.P.J. Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy. Cell 162: 314-327 (2015).

  • Prizes and Awards

    Foreign Member, The Royal Society, 2014

    Pauling Lectureship, Stanford University, 2012

    William Silen Lifetime Achievement in Mentoring Award, 2011

    Harland Wood Memorial Lecture, Case Western Reserve University, 2011

    UCSD/Merck Life Sciences Achievement Award 2007 Hans Neurath Lecturer, University of Washington, Seattle, 2007

    Royal Swedish Academy of Sciences, Gregori Aminoff Prize in Crystallography, 2006

    Fellow, American Association for the Advancement of Science, 2005

    Bristol Myers Squibb Distinguished Achievement Award in Infectious Disease Research, 2005

    Paul Ehrlich and Ludwig Darmstaedter Prize, 2001

Who he is

Stephen C. Harrison is Giovanni Armenise-Harvard Professor of Basic Medical Sciences, Harvard Medical School and Boston Children’s Hospital, and Investigator in the Howard Hughes Medical Institute.

He obtained his B.A. from Harvard in 1963 and his Ph.D. (Biophysics) from Harvard in 1968. He has served on the Harvard faculty since 1971. Between 1972 and 1996, he was Chair of the Board of Tutors in Biochemical Sciences, Harvard’s undergraduate program in biochemistry; he was Chair of the Department of Biochemistry and Molecular Biology (Faculty of Arts & Sciences) from 1988-1992, and Acting Chair of the Department of Biological Chemistry and Molecular Pharmacology (Harvard Medical School) from 2009-2012.

He is also head of the Laboratory of Molecular Medicine, Boston Children’s Hospital. For many years, his research laboratory was linked closely with that of the late Don C. Wiley. Dr. Harrison is a member of the National Academy of Sciences, a fellow of the American Academy of Arts and Sciences, a member of the American Philosophical Society, and a foreign member of EMBO.

He received the Louisa Gross Horwitz Prize (with Don Wiley and Michael Rossmann) in 1990, the ICN International Prize in Virology in 1998, and the Paul Ehrlich and Ludwig Darmstaedter Prize (with Michael Rossmann) in 2001.

What he does

Harrison has made important contributions to structural biology, most notably by determining and analyzing the structures of viruses and viral proteins, by crystallographic analysis of protein/DNA complexes, and by structural studies of protein-kinase switching mechanisms.

The initiator of high-resolution virus crystallography, he has moved from his early work on tomato bushy stunt virus (1978) to the study of more complex human pathogens, including the capsid of human papillomavirus, the envelope of dengue virus, rotavirus particles, and several components of HIV. He has also turned some his research attention to even more complex subcellular assemblies, such as clathrin coated vesicles and kinetochores.