Steven McCarroll

  • Latest publications

    Macosko EZ, Basu A, Satija R, Nemesh J, Shekhar K, Goldman M, Tirosh I, Bialas AR, Kamitaki N, Martersteck EM, Trombetta JJ, Weitz DA, Sanes JR, Shalek AK, Regev A, McCarroll SA. Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets. Cell 161:1202-14. 2015

    Handsaker RE, Doren VV, Berman JR, Genovese G, Kashin S, Boettger LM, McCarroll SA. Large multiallelic copy number variations in humans. Nat Genet 47: 296-303, 2015

    Genovese G, Kähler AK, Handsaker R, Lindberg J, Rose SA, Bakhourn SF, Chambert K, Mick E, Neale BM, Fromer M, Purcell SM, Svantesson O, Landén M, Höglund M, Lehmann S, Gabriel SB, Moran JL, Lander ES, Sullivan PF, Sklar P, Grönberg H, Hultman CM, McCarroll SA. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. NEJM 371: 2477-87, 2014

    Koren A, Handsaker RE, Kamitaki N, Karlić R, Ghosh S, Polak P, Eggan K, McCarroll SA. Genetic variation in human DNA replication timing. Cell 159: 1015-26, 2014.

    Genovese G, Handsaker RE, Li H, Altemose N, Lindgren AM, Chambert K, Pasaniuc B, Price AL, Reich D, Morton CC, Pollak MR, Wilson JG, McCarroll SA. Using population admixture to help complete maps of the human genome. Nat Genet 45: 406-14, 2013.

  • Prizes and Awards

    Armenise-Harvard Junior Faculty Grant, Department of Genetics: “Active Alu Retrotransposition in the Human Genome”, 2011

Who he is

Steve McCarroll is an institute member of the Broad Institute of MIT and Harvard, and director of genetics for the Broad’s Stanley Center for Psychiatric Research. He is also associate professor in Harvard Medical School’s Department of Genetics. He earned his Ph.D. in neuroscience at the University of California, San Francisco in the lab of Cori Bargmann. He completed his postdoctoral fellowship in the lab of David Altshuler (formerly of the Broad, Harvard, and MIT) studying human genome variation and the genetic basis of common disease.

What he does 

McCarroll’s research draws upon his training in molecular neuroscience and human genetics. McCarroll and the scientists in his lab use genetics, molecular biology, and novel approaches for single-cell analysis to reveal the ways in which genomes vary from person to person and the mechanisms by which such variation contributes to human disease. By applying new molecular and computational approaches to study the brain, he hopes to uncover the key molecular and cellular events in the development of schizophrenia and other brain illnesses. The hope is that such discoveries will lead to new, innovative therapies.

McCarroll’s human genome research has revealed that human genomes commonly vary at large scales, exhibiting deletion, duplication, inversion, and other rearrangements of long genomic segments. His lab has developed widely used approaches for identifying and characterizing such variation in people’s genomes.

McCarroll’s lab also recently developed a technology (called Drop-Seq) for high-throughput single- cell analysis of tens of thousands of individual cells at once. Scientists in the lab are using the approach to understand brain function and dysfunction in terms of the behavior of individual cells.

News from the Lab

By combining human genetics with these new biological tools, McCarroll’s lab is working to discover how genetic risk factors give rise to key molecular and cellular events in the development of schizophrenia and bipolar disorder. Their work combines genome-wide data, collected from tens of thousands of patients, with focused molecular biological experiments in neurons and brains. McCarroll and his group seek to understand how human biology changes under the influence of these genetic variants – what genes and proteins are affected and in what populations of cells, and how the molecular biology of these cells is affected as a consequence.