Nico Mitro, 2008

  • Latest publications

    Mitro N*, Cermenati G*, Brioschi E, Abbiati F, Audano M, Giatti S, Crestani M, De Fabiani E, Azcoitia I, Garcia-Segura LM, Caruso D, Melcangi RC.“Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy”. J Steroid Biochem Mol Biol. 2014 Mar 4;143C:115-121. * Both first author

    Fiorino E, Giudici M, Ferrari A, Mitro N, Caruso D, De Fabiani E, Crestani M. “The sirtuin class of histone deacetylases: Regulation and roles in lipid metabolism”. IUBMB Life. 2014 Feb;66(2):89-99.

    Melcangi RC, Giatti S, Calabrese D, Pesaresi M, Cermenati G, Mitro N, Viviani B, Garcia-Segura LM, Caruso D. Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions. Prog Neurobiol. 2014 Feb;113:56-69.

    Gilardi F, Giudici M, Mitro N, Maschi O, Guerrini U, Rando G, Maggi A, Cermenati G, Laghezza A, Loiodice F, Pochetti G, Lavecchia A, Caruso D, De Fabiani E, Bamberg K, Crestani M. “LT175 is a novel PPARα/γ ligand with potent insulin sensitizing effects and reduced adipogenic properties”. J Biol Chem. 2014 Jan 22.

    Cermenati G, Brioschi E, Abbiati F, Melcangi RC, Caruso D, Mitro N. “Liver X receptors, nervous system, and lipid metabolism”. J Endocrinol Invest. 2013 Jun;36(6):435-43.

Career Development Award Project Title

“Transcriptional link between diabetes and atherosclerosis”, 2008

Who he is

Biochemist Nico Mitro established at the age of 33 a research unit in the Laboratory of Molecular Biology of Metabolism and Mass Spectrometry at the University of Milan, where he is currently Group Leader. After working at the Scripps Research Institute in La Jolla, California, he returned to Italy in 2008 thanks to the Armenise-Harvard Career Development Award.

What he does

During his research period in the United States, Mitro concentrated on the study of glucose metabolism, focusing mainly on diabetes and on one of its complications, atherosclerosis. His experiments, funded by the American Heart Association (AHA), gave him the opportunity to use the most advanced genomic platforms and thus gain technological expertise. Expertise that he was able to bring to Italy and to his new laboratory at the Department of Pharmacological Sciences,University of Milan.

Mitro and his team’s research aims to understand the mechanisms that generate the better-known complications of diabetes, such as atherosclerosis and neuropathy.

Why do high levels of glucose give rise to these diseases? And what are the mechanisms underlying the most common forms of neuropathy and atherosclerosis? These are very important questions, as 50-60% of people with diabetes develop atherosclerosis and/or neuropathy and an increasing percentage of the population suffers from diabetes.

The approach used in Mitro’s laboratory is highly interdisciplinary and applies advanced technologies in genomics, metabolomics and bioinformatics analysis.

News from the lab

Recently Mitro and colleagues have focused on the specific complications caused by peripheral neuropathy. In particular, in a study published in Cell Metabolism in April 2015, they have shown for the first time the fundamental role of the endogenous synthesis of fatty acids in the development of peripheral neuropathy.