Davide Cacchiarelli, 2017

  • Latest Publications

    Cacchiarelli D*, Trapnell C*, Ziller MJ*, Soumillon M, Cesana M, Karnik R, Donaghey J, Smith ZD, Ratanasirintrawoot S, Zhang X, Ho Sui SJ, Wu Z, Akopian V, Gifford CA, Doench J, Rinn JL, Daley GQ, Meissner A, Lander ES, Mikkelsen TS. Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency. Cell. 2015 Jul 16; 162(2):412-24. PMID: 26186193; PMCID: PMC4511597.

    Ziller MJ, Edri R, Yaffe Y, Donaghey J, Pop R, Mallard W, Issner R, Gifford CA, Goren A, Xing J, Gu H, Cacchiarelli D, Tsankov AM, Epstein C, Rinn JL, Mikkelsen TS, Kohlbacher O, Gnirke A, Bernstein BE, Elkabetz Y, Meissner A. Dissecting neural differentiation regulatory networks through epigenetic footprinting. Nature. 2015 Feb 19; 518(7539):355-9. PMID: 25533951; PMCID: PMC4336237.

    Trapnell C*, Cacchiarelli D*, Grimsby J, Pokharel P, Li S, Morse M, Lennon NJ, Livak KJ, Mikkelsen TS, Rinn JL. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat Biotechnol. 2014 Apr; 32(4):381-6. PMID: 24658644; PMCID: PMC4122333.

  • Prizes and Awards

    Rita Levi-Montalcini Assistant Professorship, 2017

    European Research Council Starting Grant, 2017

    Start-up Grant, Fondazione Telethon, 2017

    Career Development Award, Armenise-Harvard Foundation, 2017

    Heritage Prize, Societa’ Italiana di Biochimica, 2016

    Human Frontier Science Program Fellow, 2012

    Microsoft Research PhD Student, 2007

Career Development Award Project Title

“A functional genomics framework to investigate the molecular basis of rare genetic diseases”, 2017

Who he is

Davide Cacchiarelli grew up in Rome where he carried out his undergraduate studies in Biotechnology and Biology. He obtained a Master Degree and a Doctorate Degree in Genetics and Molecular Biology from SAPIENZA – University of Rome, working on mechanisms of RNA regulation. In 2011 he moved to The Broad Institute of MIT and Harvard and The Department of Stem Cell and Regenerative Biology at Harvard University to focus his research on the rules governing cell fate transitions and reprogramming using genomic approaches.

He returned to Italy in 2017 thanks to the Armenise-Harvard Foundation Career Development Award and now he leads a young research group focused on understanding the dynamics of cell fate decisions at TIGEM, the Telethon Institute of Genetics and Medicine in Naples.

What he does

Davide Cacchiarelli’s work aims to identify the mechanisms controlling cell fate decisions during cellular differentiation, conversion and reprogramming, and how such processed are affected by genetic mutations of key regulatory proteins including transcription factors. To achieve this goal he proposes to integrate descriptive, functional and single cell genomics to dissect how genetic elements and their variants impinge on the temporal and spatial control of gene expression.

News from the Lab

Davide Cacchiarelli is currently working to set up the Laboratory of Integrative Genomics at TIGEM, bringing together an interdisciplinary approach engaging stem cell biology, cellular engineering, genomic approaches and mathematical modeling.

  • Contacts

    Davide Cacchiarelli
    Armenise/Harvard Laboratory of Integrative Genomics
    Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli (NA)
    e-mail: d.cacchiarelli@tigem.it
    office: +39 081 19230600