Dario Bonanomi, 2015

  • Latest publications

    Amin ND, Bai G, Klug JR, Bonanomi D, Pankratz MT, Gifford WD, Hinckley CA, Sternfeld MJ, Driscoll SP, Dominguez B, Lee KF, Jin X, Pfaff SL. Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. Science. 2015 Dec 18;350(6267):1525-9.

    Wang L, Mongera A, Bonanomi D, Cyganek L, Pfaff SL, Nüsslein-Volhard C, Marquardt T. A conserved axon type hierarchy governing peripheral nerve assembly. Development. 2014. 141: 1-9

    Bonanomi D, Chivatakarn O, Bai G, Abdesselem H, Lettieri K, Marquardt T, Pierchala BA, Pfaff SL. Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals. Cell. 2012. 148:568-582

    Bai G, Chivatakarn O, Bonanomi D, Lettieri K, Franco L, Xia C, Stein E, Ma L, Lewcock JW, Pfaff SL. Presenilin-dependent receptor processing is required for axon guidance. Cell. 2011. 144:106-118

    Bonanomi D, Pfaff SL. Motor axon pathfinding. Cold Spring Harb Perspect Biol. 2010. 2:a001735

    Gallarda, BW, Bonanomi D, Muller D, Brown A, Alaynick WA, Andrews SE, Lemke G, Pfaff SL, Marquardt T. Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling. Science. 2008. 320:233-236

Career Development Award Project Title

“Development and Homeostasis of Spinal Motor Neuron Connectivity”, 2015

Who he is

Milan, London, San Diego, and back to Milan again: the career path of molecular biologist Dario Bonanomi continues where it began, at the San Raffaele Scientific Institute. Here he has become Group Leader of the new Molecular Neurobiology Laboratory, funded by the Armenise-Harvard Foundation. Bonanomi is the 2015 winner of the Career Development Award, and returned to Italy from the United States in December of that year.

What he does

Bonanomi’s main research activity focuses on the molecular mechanisms that regulate formation of complex neural networks in our brain. During his PhD at the Open University in London, he worked in particular on membrane traffic in developing neurons and in synaptic terminals.

He left for the United States in 2006, and joined the Gene Expression Laboratory at the Salk Institute in San Diego, led by Samuel Pfaff, where he became interested in the oriented growth of axons, a fundamental biological process for the formation of neural circuits.

News from the Lab

The Laboratory of Molecular Neurobiology that Bonanomi is setting up at the San Raffaele aims to identify genetic and molecular factors that allow spinal motor neurons to establish and maintain long distance contact with muscle fibers. These mechanisms play a key role in motor control, and studying these mechanisms may help to understand how motor neurons are damaged in many degenerative diseases.

Bonanomi’s research is supported by the Armenise-Harvard Foundation and the European Research Council Starting Grant.