Alberto Bacci, 2005

Career Development Award Project Title

“Self-inhibition in Neocortical GABAergic Interneurons: Mechanisms and Function”, 2005

Who he is

Neuroscientist Alberto Bacci studied at the University of Milan where he obtained a B.Sc and then in 2000 a doctorate in pharmacology and experimental therapeutics. He completed a period of postdoctoral research in the Department of Neurology at Stanford University, in the United States. Upon his return to Italy in 2005, he went to lead a research team at EBRI (European Institute for Brain Research) and then in 2011 he moved to ICM (Brain & Spine Institute), Paris, France.

What he does

In music, the pauses between the notes are just as important as the notes themselves. The same applies to the brain, where the inhibition of neuronal activity is as important as the excitation of neurons for fine-tuning the activity of the nervous system and for communication between nerve cells.

Inhibition maintains a balance between inhibition and excitation in neural networks. It prevents excitability from spreading in an uncontrolled way from one neuron to another across the synapse, and keeps it confined to where it is needed and where it has a function in that particular moment. In short, it acts as a switch.

Malfunction of inhibitory nerve cells underlies epilepsy, and several psychiatric diseases, such as schizophrenia and autism.

Alberto Bacci’s team is studying how a particular class of neurons, interneurons, carries out its inhibitory work. The lab is dealing with neurons whose axons reach a single brain area and mostly use one neurotransmitter, GABA, to communicate with one another.

They are located in the cortex, the place where information coming from the sensory systems is integrated and used for higher cognitive functions. These neurons are rather like the brain’s conductors because they give large populations of neurons the “tempo” of excitation, modulating their oscillatory activity.

News from the lab

Bacci’s work focuses on understanding the connectivity logic of cortical circuits. In particular, he studies how a highly diverse population of GABAergic interneurons performs various forms of plastic modulation of cortical circuits.

To do so, he employs a wide range of techniques including single- and multiple-cell electrophysiology, imaging, optogenetics, neuroanatomy and cell biology.